MAFA anticorps (Biotin)

N° du produit ABIN729900

Détail du produit anti-MAFA anticorps (Biotin)

Antigène: MAFA (Transcription Factor MafA (MAFA))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAFA est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Mafa

Isotype: IgG

Information d'application

Indications d'application: WB: (1:100-1000), IHC-P: (1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MAFA

Antigène: MAFA (Transcription Factor MafA (MAFA))

Autre désignation: Mafa (MAFA Produits)

Sujet:

Synonyms: Mafa homolog, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A,Pancreatic beta-cell-specic transcriptional activator,avianV-maf musculoaponeurotic fibrosarcoma oncogene homolog A, MAFA_MOUSE.

Background: Insulin gene expression is regulated by several islet-enriched transcription factors. However, MAFA is the only beta cell-specific activator. MAFA selectively induces endogenous insulin transcription in non-beta cells. MAFA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MAFA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.

ID gène: 389692

Pathways: Hormone Transport