TRIM32 anticorps (AA 301-400) (Biotin)

N° du produit ABIN730335

Détail du produit anti-TRIM32 anticorps (Biotin)

Antigène: TRIM32 (Tripartite Motif Containing 32 (TRIM32))

Épitope: AA 301-400

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM32 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse TRIM32

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TRIM32

Antigène: TRIM32 (Tripartite Motif Containing 32 (TRIM32))

Autre désignation: TRIM32/BBS11 (TRIM32 Produits)

Synonymes: anticorps BBS11, anticorps HT2A, anticorps LGMD2H, anticorps TATIP, anticorps 1810045E12Rik, anticorps 3f3, anticorps Zfp117, anticorps tripartite motif containing 32, anticorps tripartite motif-containing 32, anticorps TRIM32, anticorps trim32, anticorps Trim32

Sujet:

Synonyms: 72 kda Tat interacting Protein, BBS11, HT2A, LGMD2H, Limb girdle muscular dystrophy 2H autosomal recessive, Limb girdle muscular dystrophy 2H, Muscular dystrophy Hutterite type, TAT interactive protein 72KD, TATIP, Tripartite Mot Containing Protein 32, Zinc Finger Protein HT2A, TRI32_MOUSE.

Background: Tripartite motif-containing protein 32 (TRIM32) belongs to the tripartite motif (TRIM) protein family. TRIM32, like all TRIM proteins, contains a domain structure composed of a B-box, a RING-finger and a coiled-coil motif. Additionally, TRIM32 has six C-terminal NHL domains, it is expressed mainly in the skeletal muscle. The TRIM32 gene encodes an E3 ubiquitin ligase, a protein that attaches ubiquitin to a lysine residue on a target protein and acts in conjunction with ubiquitin-conjugating enzymes UbcH5a, UbcH5c and UbcH6. Mutations in the TRIM32 gene cause two forms of autosomal recessive muscular dystrophy designated limb girdle muscular dystrophy type 2H (LGMD2H) and sarcotubular myopathy (STM). TRIM32 mutations can also result in Bardet-Biedl syndrome (BBS), an autosomal recessive disorder characterized by pigmentary retinopathy, polydactyly, hypogenitalism, renal abnormalities, learning disabilities and obesity.

ID gène: 22954

Pathways: Negative Regulation of intrinsic apoptotic Signaling