PAK3 anticorps (pSer139)

N° du produit ABIN732593

Détail du produit anti-PAK3 anticorps

Antigène: PAK3

Épitope: pSer139

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAK3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human PAK3 around the phosphorylation site of (Ser139)

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PAK3

Antigène: PAK3

Autre désignation: PAK3 (PAK3 Produits)

Synonymes: anticorps CDKN1A, anticorps MRX30, anticorps MRX47, anticorps OPHN3, anticorps PAK3beta, anticorps bPAK, anticorps hPAK3, anticorps PAK-3, anticorps Pak65alpha, anticorps Pak65beta, anticorps Stk4, anticorps beta-PAK, anticorps XPak3, anticorps bpak, anticorps cdkn1a, anticorps mrx30, anticorps mrx47, anticorps ophn3, anticorps pak3, anticorps pak3-A, anticorps pak3beta, anticorps p21 (RAC1) activated kinase 3, anticorps p21 protein (Cdc42/Rac)-activated kinase 3, anticorps p21 protein (Cdc42/Rac)-activated kinase 3 L homeolog, anticorps PAK3, anticorps Pak3, anticorps pak3.L

Sujet:

Synonyms: PAK3_HUMAN, Beta PAK, bPAK, CDKN1A, hPAK3, Mental retardation X linked 30, MRX30, MRX47, Oligophrenin 3, OPHN3, p21 activated kinase 3, p21 CDKN1A activated kinase 3, PAK-3, PAK3 p21 protein Cdc42/Rac-activated kinase 3, PAK3beta, Pak65alpha, Pak65beta, Serine threonine protein kinase PAK 3, Stk4.

Background: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.

ID gène: 5063