Ephrin A1 anticorps (AA 101-205)

N° du produit ABIN734108

Détail du produit anti-Ephrin A1 anticorps

Antigène: Ephrin A1 (EFNA1)

Épitope: AA 101-205

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ephrin A1 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain

Homologie: Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Ephrin A1

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Ephrin A1

Antigène: Ephrin A1 (EFNA1)

Autre désignation: Ephrin A1 (EFNA1 Produits)

Synonymes: anticorps Xefrin-A1, anticorps b61, anticorps ecklg, anticorps efl1, anticorps efna1, anticorps efna1a, anticorps elfa-a, anticorps epha1, anticorps eplg1, anticorps lerk1, anticorps tnfaip4, anticorps xelf-a', anticorps xelfa, anticorps AI325262, anticorps B61, anticorps Efl1, anticorps Epl1, anticorps Eplg1, anticorps Lerk1, anticorps ECKLG, anticorps EFL1, anticorps EPLG1, anticorps LERK-1, anticorps LERK1, anticorps TNFAIP4, anticorps efna1b, anticorps MGC130661, anticorps ephrin-A1 S homeolog, anticorps ephrin-A1, anticorps ephrin A1, anticorps ephrin-A1b, anticorps ephrin-A1 L homeolog, anticorps efna1.S, anticorps efna1, anticorps EFNA1, anticorps efna1b, anticorps Efna1, anticorps efna1.L

Sujet:

Synonyms: Ephrin-A1, EFNA1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, EPLG1, LERK1, TNFAIP4

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

ID gène: 1942

UniProt: P20827

Pathways: Signalisation RTK