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Lamin A/C anticorps (AA 1-100)

LMNA Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN735188
  • Antigène Voir toutes Lamin A/C (LMNA) Anticorps
    Lamin A/C (LMNA)
    Épitope
    • 10
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reactivité
    • 133
    • 74
    • 71
    • 27
    • 15
    • 14
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 97
    • 46
    • 2
    • 1
    Lapin
    Clonalité
    • 96
    • 50
    Polyclonal
    Conjugué
    • 115
    • 9
    • 8
    • 6
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Lamin A/C est non-conjugé
    Application
    • 120
    • 55
    • 53
    • 49
    • 32
    • 30
    • 30
    • 21
    • 14
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human lamin A
    Isotype
    IgG
    Top Product
    Discover our top product LMNA Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Yi, Pan, Pan, Song, Hu, Wang, Pan, Lu: "BmICE-2 is a novel pro-apoptotic caspase involved in apoptosis in the silkworm, Bombyx mori." dans: Biochemical and biophysical research communications, Vol. 445, Issue 1, pp. 100-6, (2014) (PubMed).

  • Antigène
    Lamin A/C (LMNA)
    Autre désignation
    lamin A/C (LMNA Produits)
    Sujet

    Synonyms: FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMN1, LMNC, PRO1, CDCD1, CMD1A, FPLD2, LMNL1, CMT2B1, LGMD1B, Prelamin-A/C, LMNA

    Background: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

    ID gène
    4000
    UniProt
    P02545
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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