MMP17 anticorps (AA 101-200) (Biotin)

N° du produit ABIN735535

Détail du produit anti-MMP17 anticorps (Biotin)

Antigène: MMP17 (Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17))

Épitope: AA 101-200

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP17 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MMP17

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MMP17

Antigène: MMP17 (Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17))

Autre désignation: MMP-17 (MMP17 Produits)

Synonymes: anticorps MT4-MMP, anticorps CBTF, anticorps DRBF, anticorps DRBP76, anticorps MMP4, anticorps MPHOSPH4, anticorps MPP4, anticorps NF-AT-90, anticorps NF110, anticorps NF110b, anticorps NF90, anticorps NF90a, anticorps NF90b, anticorps NFAR, anticorps NFAR-1, anticorps NFAR2, anticorps TCP110, anticorps TCP80, anticorps MT4MMP, anticorps MTMMP4, anticorps mmp17, anticorps matrix metallopeptidase 17, anticorps interleukin enhancer binding factor 3, anticorps matrix metallopeptidase 17a, anticorps MMP17, anticorps ILF3, anticorps Mmp17, anticorps mmp17a

Sujet:

Synonyms: Matrix metalloproteinase-17, MMP-17, MMP17, MTMMP 4, Matrix metalloproteinase 17, Matrix metalloproteinase 17 membrane inserted, Membrane type 4 matrix metalloproteinase, Membrane type matrix metalloproteinase 4, MMP 17, MT MMP 4, MT MMP4, MT4 MMP, MT4MMP.

Background: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP17 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines. Treatment of cells with Concanavolin A or the phorbol ester TPA stimulates production of MMP17 in some cell types, and the enzyme can be recovered in cell lysates. Shed forms of MMP17 have also been reported.

ID gène: 4326