SOCS2 anticorps (AA 1-100)

N° du produit ABIN736028

Détail du produit anti-SOCS2 anticorps

Antigène: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Épitope: AA 1-100

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Socs 2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-SOCS2 (ABIN736028)

Shin, Riew, Park, Pak, Lee: "Expression of SOCS2 mRNA and protein in the ischemic core and penumbra after transient focal cerebral ischemia in rats." dans: Cell and tissue research, Vol. 364, Issue 1, pp. 67-81, (2016) (PubMed).

Letellier, Schmitz, Baig, Beaume, Schwartz, Frasquilho, Antunes, Marcon, Nazarov, Vallar, Even, Haan: "Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer." dans: British journal of cancer, Vol. 111, Issue 4, pp. 726-35, (2014) (PubMed).

Zhu, Dai, Han, He, Mo, Chen, Chen, Wu, Yang, Jiang, Chen, Sun, Zhong: "Expression of SOCSs in human prostate cancer and their association in prognosis." dans: Molecular and cellular biochemistry, Vol. 381, Issue 1-2, pp. 51-9, (2013) (PubMed).

Détails sur SOCS2

Antigène: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Autre désignation: Socs 2 (SOCS2 Produits)

Synonymes: anticorps CIS2, anticorps Cish2, anticorps SOCS-2, anticorps SSI-2, anticorps SSI2, anticorps STATI2, anticorps Cish1, anticorps Socs-1, anticorps Socs-2, anticorps si:dkey-202b22.1, anticorps socs2, anticorps cis2, anticorps ssi2, anticorps cish2, anticorps ssi-2, anticorps socs-2, anticorps stati2, anticorps 8030460M17, anticorps AI527257, anticorps AW108012, anticorps D130043N08Rik, anticorps JAB, anticorps hg, anticorps Cradd, anticorps Socs2, anticorps suppressor of cytokine signaling 2, anticorps suppressor of cytokine signaling 1, anticorps death domain-containing protein CRADD, anticorps suppressor of cytokine signaling 2 S homeolog, anticorps SOCS2, anticorps Socs1, anticorps Socs2, anticorps socs2, anticorps LOC100716104, anticorps socs2.S

Sujet:

Synonyms: CIS2, SSI2, Cish2, SSI-2, SOCS-2, STATI2, Suppressor of cytokine signaling 2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SOCS2

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

ID gène: 8835

UniProt: O14508

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus