NRF2 anticorps (AA 430-480)

N° du produit ABIN737271

Cité dans 22 publications. Cet anticorps anti-NRF2 Polyclonal Lapin (ABIN737271) détecte spécifiquement NRF2 dans WB, ELISA, FACS, IHC (p), IF (cc), IF (p) et IHC (fro). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour NRF2 anticorps (AA 430-480) (ABIN737271)

Antigène: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NRF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-NRF2 anticorps

Épitope: AA 430-480

Réactivité croisée: Poulet, Humain, Souris, Porc, Lapin, Rat

Homologie: Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Nrf2

Isotype: IgG

Information d'application

Indications d'application: WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-NRF2 (ABIN737271)

Xu, Zheng, Liu, Li, Yang, Shang: "Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 6, pp. 2091-2104, (2018) (PubMed).

Zeng, Li, Zhang, Liu, Li, Xiong, He, Wang, Ye: "Tert-Butylhydroquinone Protects Liver Against Ischemia/Reperfusion Injury in Rats Through Nrf2-Activating Anti-Oxidative Activity." dans: Transplantation proceedings, Vol. 49, Issue 2, pp. 366-372, (2017) (PubMed).

Zhang, Dong, Chen, Liu, Huang, Zhong, Cheng, Wang: "Nrf2 mediates the protective effects of homocysteine by increasing the levels of GSH content in HepG2 cells." dans: Molecular medicine reports, Vol. 16, Issue 1, pp. 597-602, (2017) (PubMed).

Yu, Bei, Li, Han, Zhong, Liu, Zhao, Zhu, Zhao: "In vitro the differences of inflammatory and oxidative reactions due to sulfur mustard induced acute pulmonary injury underlying intraperitoneal injection and intratracheal instillation in rats." dans: International immunopharmacology, Vol. 47, pp. 78-87, (2017) (PubMed).

Shen, Wu, Wang, Zhao, Zhang, Li, Zhao: "Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis." dans: International immunopharmacology, Vol. 46, pp. 16-22, (2017) (PubMed).

Zhang, Wang, Hao, Wang, Zhang, Muhammad, Qi, Li, Sun: "Nrf2 is crucial for the down-regulation of Cyp7a1 induced by arachidonic acid in Hepg2 cells." dans: Environmental toxicology and pharmacology, Vol. 52, pp. 21-26, (2017) (PubMed).

Cao, Huang, Dou, Xiang, Dong: "Cyanidin suppresses autophagic activity regulating chondrocyte hypertrophic differentiation." dans: Journal of cellular physiology, Vol. 233, Issue 3, pp. 2332-2342, (2017) (PubMed).

Kouam, Yuan, Njayou, He, Tsayem, Oladejo, Song, Moundipa, Gao: "Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity." dans: Frontiers in pharmacology, Vol. 8, pp. 653, (2017) (PubMed).

Jiang, Li, He, Yao, Bian, Wang, Zhu: "Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats." dans: Inflammation, Vol. 39, Issue 6, pp. 1853-1861, (2016) (PubMed).

Tang, Gao, Mao, He, Liu, Cai, Lin, Wu: "Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways." dans: Cell stress & chaperones, Vol. 21, Issue 2, pp. 239-49, (2016) (PubMed).

Wang, Peng, Wei, Wei, Wang, Ma, Yao, Fu, Zu: "Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway." dans: Biochimica et biophysica acta, Vol. 1850, Issue 9, pp. 1751-61, (2015) (PubMed).

Yu, Shi, Zhao, Sun, Gao, Sun, Qi: "Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway." dans: Cardiovascular toxicology, (2015) (PubMed).

Lv, Mao, Wu, Lu, Ding, Gu, Wu, Shi: "Neuroprotective effect of allicin in a rat model of acute spinal cord injury." dans: Life sciences, Vol. 143, pp. 114-23, (2015) (PubMed).

Lee, Lee, Wu: "Actinidia callosa peel (kiwi fruit) ethanol extracts protected neural cells apoptosis induced by methylglyoxal through Nrf2 activation." dans: Pharmaceutical biology, Vol. 52, Issue 5, pp. 628-36, (2014) (PubMed).

Wang, Fang, Huang, Chen, Fan, Wang: "The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats." dans: Environmental toxicology and pharmacology, Vol. 35, Issue 1, pp. 109-16, (2013) (PubMed).

Lee, Hsu, Huang, Chang, Hsu, Pan: "Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats." dans: Journal of agricultural and food chemistry, Vol. 61, Issue 6, pp. 1288-98, (2013) (PubMed).

Hsu, Lee, Li, Hsu, Pan: "Monascin and AITC attenuate methylglyoxal-induced PPAR? phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation." dans: Journal of agricultural and food chemistry, Vol. 61, Issue 25, pp. 5996-6006, (2013) (PubMed).

Lee, Hsu, Hsu, Pan: "Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid." dans: Free radical biology & medicine, Vol. 60, pp. 7-16, (2013) (PubMed).

Lee, Lee, Cheng, Chang, Hsu, Wu: "Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 492-8, (2013) (PubMed).

Détails sur NRF2

Antigène: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Autre désignation: Nrf2

Sujet:

Synonyms: NRF2, Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2, like 2, NFE2L2

Background: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

ID gène: 4780

UniProt: Q16236

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling