CADM1 anticorps (AA 365-442)
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- Antigène Voir toutes CADM1 Anticorps
- CADM1 (Cell Adhesion Molecule 1 (CADM1))
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Épitope
- AA 365-442
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CADM1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain, Rat
- Homologie
- Mouse,Dog,Chicken
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human TSLC1
- Isotype
- IgG
- Top Product
- Discover our top product CADM1 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity." dans: International journal of nanomedicine, Vol. 9, pp. 4829-46, (2014) (PubMed).
: "Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ..." dans: Toxicology and applied pharmacology, Vol. 251, Issue 1, pp. 70-8, (2011) (PubMed).
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Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity." dans: International journal of nanomedicine, Vol. 9, pp. 4829-46, (2014) (PubMed).
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- Antigène
- CADM1 (Cell Adhesion Molecule 1 (CADM1))
- Autre désignation
- TSLC1 (CADM1 Produits)
- Synonymes
- anticorps BL2, anticorps IGSF4, anticorps IGSF4A, anticorps NECL2, anticorps Necl-2, anticorps RA175, anticorps ST17, anticorps SYNCAM, anticorps TSLC1, anticorps sTSLC-1, anticorps sgIGSF, anticorps synCAM1, anticorps bl2, anticorps igsf4, anticorps igsf4a, anticorps necl-2, anticorps necl2, anticorps ra175, anticorps sgigsf, anticorps st17, anticorps stslc-1, anticorps syncam, anticorps syncam1, anticorps tslc1, anticorps xnecl2, anticorps 2900073G06Rik, anticorps 3100001I08Rik, anticorps AI987920, anticorps Bl2, anticorps Igsf4, anticorps Igsf4a, anticorps Necl2, anticorps RA175A, anticorps RA175B, anticorps RA175C, anticorps RA175N, anticorps SgIGSF, anticorps SynCam, anticorps Tslc1, anticorps SynCAM1, anticorps cell adhesion molecule 1, anticorps cell adhesion molecule 1 L homeolog, anticorps CADM1, anticorps cadm1.L, anticorps Cadm1
- Sujet
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Synonyms: BL2, ST17, IGSF4, NECL2, RA175, TSLC1, IGSF4A, Necl-2, SYNCAM, sgIGSF, sTSLC-1, synCAM1, Cell adhesion molecule 1, Immunoglobulin superfamily member 4, Nectin-like protein 2, Spermatogenic immunoglobulin superfamily, Synaptic cell adhesion molecule, Tumor suppressor in lung cancer 1, TSLC-1, CADM1
Background: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
- ID gène
- 23705
- UniProt
- Q9BY67
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation
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