Cyclin D2 anticorps (AA 161-288)

N° du produit ABIN738366

Détail du produit anti-Cyclin D2 anticorps

Antigène: Cyclin D2 (CCND2)

Épitope: AA 161-288

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Cyclin D2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Cyclin D2 (ABIN738366)

Wang, Wu, Gao, Chen, Gu, Ding, Guo: "Elevated toll-like receptor 3 inhibits pancreatic ?-cell proliferation through G1 phase cell cycle arrest." dans: Molecular and cellular endocrinology, Vol. 377, Issue 1-2, pp. 112-22, (2013) (PubMed).

Détails sur Cyclin D2

Antigène: Cyclin D2 (CCND2)

Autre désignation: Cyclin D2 (CCND2 Produits)

Synonymes: anticorps si:ch211-240j22.2, anticorps ccnd2, anticorps CCND2, anticorps kiak0002, anticorps zgc:162280, anticorps LOC100224096, anticorps KIAK0002, anticorps BF642806, anticorps C86853, anticorps Vin-1, anticorps Vin1, anticorps cD2, anticorps 2600016F06Rik, anticorps AI256817, anticorps cyclin D2, b, anticorps cyclin D2 S homeolog, anticorps cyclin D2, anticorps G1/S-specific cyclin-D2, anticorps cyclin D2, a, anticorps cyclin D2 L homeolog, anticorps ccnd2b, anticorps ccnd2.S, anticorps CCND2, anticorps ccnd2, anticorps ccnd2a, anticorps Ccnd2, anticorps ccnd2.L

Sujet:

Synonyms: MPPH3, KIAK2, G1/S-specific cyclin-D2, CCND2

Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

ID gène: 894

UniProt: P30279

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases