TRAF6 anticorps (AA 441-530)

N° du produit ABIN738906

Détail du produit anti-TRAF6 anticorps

Antigène: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Épitope: AA 441-530

Reactivité: Humain, Souris, Rat, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAF6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Poulet, Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse TRAF6

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-TRAF6 (ABIN738906)

Li, Yu, Li, Liu, Jiao, Song, Lv, Qin: "Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway." dans: Scientific reports, Vol. 7, Issue 1, pp. 5843, (2017) (PubMed).

Détails sur TRAF6

Antigène: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Autre désignation: TRAF6 (TRAF6 Produits)

Synonymes: anticorps MGC:3310, anticorps RNF85, anticorps 2310003F17Rik, anticorps AI851288, anticorps C630032O20Rik, anticorps rnf85, anticorps traf6, anticorps xtraf6, anticorps CG10961, anticorps DTRAF2, anticorps Dmel\\CG10961, anticorps TRAF, anticorps TRAF2, anticorps TRAF6, anticorps Traf2, anticorps dTRAF2, anticorps dTRAF6, anticorps dTraf2, anticorps dtraf2, anticorps GB10539, anticorps fi15f02, anticorps wu:fi15f02, anticorps zgc:63704, anticorps TNF receptor associated factor 6, anticorps TNF receptor-associated factor 6, anticorps TNF receptor associated factor 6 L homeolog, anticorps TNF-receptor-associated factor 6, anticorps TNF receptor associated factor 6 S homeolog, anticorps TRAF6, anticorps Traf6, anticorps traf6.L, anticorps traf6, anticorps LOC551819, anticorps traf6.S

Sujet:

Synonyms: AI851288, 2310003F17Rik, C630032O20Rik, TNF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, Traf6

Background: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

ID gène: 22034

UniProt: P70196

Pathways: Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway