CXCR3 anticorps (AA 1-100)

N° du produit ABIN739014

Détail du produit anti-CXCR3 anticorps

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Épitope: AA 1-100

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXCR3 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody is specific for isoform 2: CXCR3B

Réactivité croisée: Humain, Souris

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CXCR3 isoform 2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur CXCR3

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Autre désignation: CXCR3 (CXCR3 Produits)

Synonymes: anticorps CD182, anticorps CD183, anticorps CKR-L2, anticorps CMKAR3, anticorps GPR9, anticorps IP10-R, anticorps Mig-R, anticorps MigR, anticorps Cd183, anticorps Cmkar3, anticorps CXCR3, anticorps cxcr3, anticorps Gpr9, anticorps CXC-R3, anticorps CXCR-3, anticorps zgc:92301, anticorps sb:eu378, anticorps C-X-C motif chemokine receptor 3, anticorps chemokine (C-X-C motif) receptor 3, anticorps chemokine (C-X-C motif) receptor 3, tandem duplicate 2, anticorps chemokine (C-X-C motif) receptor 3, tandem duplicate 1, anticorps CXCR3, anticorps Cxcr3, anticorps cxcr3, anticorps cxcr3.2, anticorps cxcr3.1

Sujet:

Synonyms: GPR9, MigR, CD182, CD183, Mig-R, CKR-L2, CMKAR3, IP10-R, C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor, CXCR3

Background: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.

ID gène: 2833

UniProt: P49682