KISS1R anticorps (AA 121-200)

N° du produit ABIN741180

Détail du produit anti-KISS1R anticorps

Antigène: KISS1R (KISS1 Receptor (KISS1R))

Épitope: AA 121-200

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KISS1R est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Sheep,Pig,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KiSS1 receptor

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-KISS1R (ABIN741180)

Luo, Li, Li, Zhang, Zhang: "Leptin/leptinR-kisspeptin/kiss1r-GnRH pathway reacting to regulate puberty onset during negative energy balance." dans: Life sciences, Vol. 153, pp. 207-12, (2016) (PubMed).

Luo, Hou, Yin, Zhang: "Expression of kisspeptin/kiss1r system in developing hypothalamus of female rat and the possible effects on reproduction development and maintenance." dans: Journal of the Chinese Medical Association : JCMA, Vol. 79, Issue 10, pp. 546-53, (2016) (PubMed).

Détails sur KISS1R

Antigène: KISS1R (KISS1 Receptor (KISS1R))

Autre désignation: Kiss1 Receptor (KISS1R Produits)

Synonymes: anticorps AXOR12, anticorps CPPB1, anticorps GPR54, anticorps HH8, anticorps HOT7T175, anticorps KISS-1R, anticorps Gpr54, anticorps KiSS-1, anticorps gpr54, anticorps gpr54-1, anticorps gpr54a, anticorps kiss1r, anticorps kiss1rl, anticorps kissr2, anticorps si:dkey-31m5.9, anticorps axor12, anticorps kissr1a, anticorps KISS1 receptor, anticorps KISS1 receptor a, anticorps KISS1R, anticorps Kiss1r, anticorps kiss1ra, anticorps kiss1r

Sujet:

Synonyms: HH8, CPPB1, GPR54, AXOR12, KISS-1R, HOT7T175, KiSS-1 receptor, G-protein coupled receptor 54, G-protein coupled receptor OT7T175, Hypogonadotropin-1, Kisspeptins receptor, Metastin receptor, KISS1R

Background: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

ID gène: 84634

UniProt: Q969F8