CD11b anticorps (AA 520-570)

N° du produit ABIN741285

Détail du produit anti-CD11b anticorps

Highlights:

• High quality CD11b Anticorps primaire for the detection of ITGAM.
• Reliable product with high standard validation data

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Épitope: AA 520-570

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD11b est non-conjugé

Application: Flow Cytometry (FACS)

Réactivité croisée: Humain, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CD11c

Isotype: IgG

Informations sur le produit:

What can the CD11b Antibody ABIN741285 be used for?: This polyclonal CD11b Antibody detects CD11b. The CD11b Antibody has been validated for various applications and can be used for the detection of CD11b and derivatives by Flow Cytometry.

What validation data is available for this CD11b Antibody?: The Anticorps primaire is referenced in 4 publications and is characterized by a proven, very high reliability. It has currently 7 product images that show its performance in a variety of applications. The product is currently available in 100 μL quantity. CD11b Antibody for the detection of CD11b and derivatives.

What is the function of CD11b?: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

Information d'application

Indications d'application: WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Références pour anticorps anti-CD11b (ABIN741285)

Ju, Xing, Yang, Zheng, Jia, Zhang, Ren: "An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model." dans: BMC immunology, Vol. 17, Issue 1, pp. 31, (2016) (PubMed).

Zhang, Wu, Hayashi, Okada, Nakanishi: "Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 8, pp. 3013-22, (2014) (PubMed).

Di Filippo, Rossi, Ferraro, Maisto, De Angelis, Ferraraccio, Rotondo, DAmico: "Involvement of proteasome and macrophages M2 in the protection afforded by telmisartan against the acute myocardial infarction in Zucker diabetic fatty rats with metabolic syndrome." dans: Mediators of inflammation, Vol. 2014, pp. 972761, (2014) (PubMed).

Ahn, Ruiz, Barber: "Intrinsic self-DNA triggers inflammatory disease dependent on STING." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 9, pp. 4634-42, (2014) (PubMed).

Détails sur CD11b

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Autre désignation: Cd11b/C (ITGAM Produits)

Synonymes: anticorps CD11b/CD18, anticorps CR3, anticorps CR3A, anticorps Cd11b, anticorps F730045J24Rik, anticorps Ly-40, anticorps MAC1, anticorps Mac-1, anticorps Mac-1a, anticorps CD11B, anticorps MAC-1, anticorps MAC1A, anticorps MO1A, anticorps SLEB6, anticorps C3bi, anticorps integrin subunit alpha M, anticorps integrin alpha M, anticorps integrin, alpha M (complement component 3 receptor 3 subunit), anticorps integrin alpha-M, anticorps ITGAM, anticorps Itgam, anticorps LOC100351865

Sujet:

Synonyms: CD11C, SLEB6, Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p15,95 alpha chain, Leukocyte adhesion receptor p15,95, ITGAX

Background: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

ID gène: 3687

UniProt: P20702

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation