ICOS anticorps (AA 51-150)

N° du produit ABIN742380

Détail du produit anti-ICOS anticorps

Antigène: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Épitope: AA 51-150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ICOS est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody may also have a secondary cross-reactivity with AP-1 complex-associated regulatory protein due to a 77 % non-contiguous sequence similarity in the corresponding immunogen region.

Réactivité croisée: Humain

Homologie: Mouse,Rat,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ICOS

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ICOS

Antigène: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Autre désignation: ICOS/CD278 (ICOS Produits)

Synonymes: anticorps ICOS, anticorps AILIM, anticorps CCLP, anticorps CRP-1, anticorps H4, anticorps Ly115, anticorps CD278, anticorps CVID1, anticorps Ailim, anticorps inducible T-cell costimulator, anticorps inducible T cell co-stimulator, anticorps inducible T-cell co-stimulator, anticorps ICOS, anticorps LOC100232284, anticorps Icos

Sujet:

Synonyms: AILIM, CD278, CVID1, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, ICOS

Background: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

ID gène: 29851

UniProt: Q9Y6W8

Pathways: Cancer Immune Checkpoints