INPP5D anticorps (pTyr1020)

N° du produit ABIN745733

Détail du produit anti-INPP5D anticorps

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Épitope: pTyr1020

Reactivité: Humain, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP5D est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Réactivité croisée: Humain, Singe, Souris

Homologie: Rat,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human SHIP1 around the phosphorylation site of Tyr1020

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur INPP5D

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Autre désignation: SHIP1 (INPP5D Produits)

Synonymes: anticorps INPP5D, anticorps 256.t00004, anticorps 13.t00027, anticorps ship, anticorps ship1, anticorps AI323613, anticorps SHIP, anticorps SHIP-1, anticorps SHIP1, anticorps s-SHIP, anticorps SIP-145, anticorps hp51CN, anticorps inositol polyphosphate-5-phosphatase D, anticorps phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, anticorps inositol polyphosphate 5-phosphatase, anticorps inositol polyphosphate-5-phosphatase D L homeolog, anticorps INPP5D, anticorps LOC100446045, anticorps inpp5d, anticorps EHI_159880, anticorps EHI_153490, anticorps inpp5d.L, anticorps LOC100380693, anticorps Inpp5d

Sujet:

Synonyms: P-SHIP1 Tyr1020, Inositol polyphosphate 5 phosphatase of 145 kDa, 4, 5-trisphosphate 5-phosphatase 1, hp51CN, hSHIP, Inositol polyphosphate 5 phosphatase 145 kDa, Inositol polyphosphate 5 phosphatase, Inositol polyphosphate 5 phosphatase D, Inositol polyphosphate-5-phosphatase of 145 kDa, INPP 5D, INPP5D, INPP5D protein, MGC104855, MGC142140, MGC142142, p150 ship, p150Ship, Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1, Phosphatidylinositol-3, SH2 containing inositol 5 phosphatase, SH2 containing inositol phosphatase isoform b, SH2 domain containing inositol 5' phosphatase 1, SH2 domain containing inositol phosphatase 1, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol-5''-phosphatase 1, SHIP 1, SHIP-1, SHIP1, SHIP1_RAT, Signaling inositol polyphosphate 5 phosphatase SIP 145, Signaling inositol polyphosphate 5 phosphatase SIP145, SIP 145, SIP-145, SIP145.

Background: SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.

ID gène: 3635

Pathways: TCR Signaling, BCR Signaling, L'effet Warburg