Smad2/3 anticorps (AA 30-80)

N° du produit ABIN747023

Détail du produit anti-Smad2/3 anticorps

Antigène: Smad2/3 (SMAD2/3) (Smad2/3 Transcription Factor (SMAD2/3))

Épitope: AA 30-80

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Smad2/3 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Réactivité croisée: Humain, Souris, Porc, Rat

Homologie: Cow,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Smad2

Isotype: IgG

Information d'application

Indications d'application: WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Smad2/3 (ABIN747023)

Chen, Qin, Zhao, Yan, Ye, Ren, Wang, Yang, Heng, Zheng, Liu: "Pulsed Magnetic Field Stimuli Can Promote Chondrogenic Differentiation of Superparamagnetic Iron Oxide Nanoparticles-Labeled Mesenchymal Stem Cells in Rats." dans: Journal of biomedical nanotechnology, Vol. 14, Issue 12, pp. 2135-2145, (2019) (PubMed).

Zhou, Yang, Shao, Wang, Yang, Huang, Zhou, Jiang, Yang: "Effects of Zearalenone Exposure on the TGF-β1/Smad3 Signaling Pathway and the Expression of Proliferation or Apoptosis Related Genes of Post-Weaning Gilts." dans: Toxins, Vol. 10, Issue 2, (2019) (PubMed).

Zhou, Zhang, Gao, Tan, Zheng, Zhao, Zhang: "Induced pluripotent stem cell-conditioned medium suppresses pulmonary fibroblast-to-myofibroblast differentiation via the inhibition of TGF-β1/Smad pathway." dans: International journal of molecular medicine, Vol. 41, Issue 1, pp. 473-484, (2018) (PubMed).

Liu, Zou, Li, Wang, Wang, Hao, Ke, Li: "RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells." dans: International journal of molecular medicine, Vol. 40, Issue 1, pp. 65-74, (2017) (PubMed).

Bai, Chu, Wang, Xiang, Yang: "BAMBI promotes porcine granulosa cell steroidogenesis involving TGF-β signaling." dans: Theriogenology, Vol. 100, pp. 24-31, (2017) (PubMed).

Wahsh, Abu-Elsaad, El-Karef, Ibrahim: "The vitamin D receptor agonist, calcipotriol, modulates fibrogenic pathways mitigating liver fibrosis in-vivo: An experimental study." dans: European journal of pharmacology, Vol. 789, pp. 362-9, (2016) (PubMed).

Wang, Zhang, Sun, Ren: "The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signaling and activation of the Nrf2/HO-1 pathway." dans: Molecular medicine reports, Vol. 14, Issue 3, pp. 2389-96, (2016) (PubMed).

Hu, Duan, Li, Wang, Wang, Chu, Sun, Liu, Wang, Lu, Wen: "Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition." dans: PLoS ONE, Vol. 11, Issue 4, pp. e0153409, (2016) (PubMed).

Tang, Gao, Mao, He, Liu, Cai, Lin, Wu: "Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways." dans: Cell stress & chaperones, Vol. 21, Issue 2, pp. 239-49, (2016) (PubMed).

Détails sur Smad2/3

Antigène: Smad2/3 (SMAD2/3) (Smad2/3 Transcription Factor (SMAD2/3))

Autre désignation: Smad2/3 (SMAD2/3 Produits)

Sujet:

Synonyms: Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2, SMAD2_HUMAN.

Background: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

ID gène: 4087

UniProt: Q15796