Smad2/3 anticorps (AA 30-80) (Biotin)

N° du produit ABIN747025

Détail du produit anti-Smad2/3 anticorps (Biotin)

Antigène: Smad2/3 (SMAD2/3) (Smad2/3 Transcription Factor (SMAD2/3))

Épitope: AA 30-80

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Smad2/3 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Porc, Rat

Homologie: Cow,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Smad2

Isotype: IgG

Information d'application

Indications d'application: WB 1:100-1000
IHC-P 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Smad2/3

Antigène: Smad2/3 (SMAD2/3) (Smad2/3 Transcription Factor (SMAD2/3))

Autre désignation: Smad2/3 (SMAD2/3 Produits)

Sujet:

Synonyms: Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2, SMAD2_HUMAN.

Background: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

ID gène: 4087

UniProt: Q15796