IL17C anticorps (AA 101-197)

N° du produit ABIN747983

Détail du produit anti-IL17C anticorps

Antigène: IL17C (Interleukin 17C (IL17C))

Épitope: AA 101-197

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL17C est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IL-17C

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-IL17C (ABIN747983)

Huang, Meng, Hong, Lin, Jin, Dong: "IL-17C is required for lethal inflammation during systemic fungal infection." dans: Cellular & molecular immunology, Vol. 13, Issue 4, pp. 474-83, (2017) (PubMed).

Huang, Yuan, Zhu, Yin, Hong, Dong, Jin, Dong: "IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 198, Issue 2, pp. 669-680, (2016) (PubMed).

Détails sur IL17C

Antigène: IL17C (Interleukin 17C (IL17C))

Autre désignation: IL-17C (IL17C Produits)

Synonymes: anticorps IL17C, anticorps il17-3, anticorps CX2, anticorps IL-17C, anticorps IL-21, anticorps interleukin 17C, anticorps interleukin 17c, anticorps IL17C, anticorps il17c, anticorps Il17c

Sujet:

Synonyms: CX2, IL-17C, Interleukin-17C, Cytokine CX2, IL17C, UNQ561/PRO1122

Background: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

ID gène: 27189

UniProt: Q9P0M4

Pathways: Cellular Response to Molecule of Bacterial Origin