IRS1 anticorps (pSer307)

N° du produit ABIN749873

Détail du produit anti-IRS1 anticorps

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Épitope: pSer307

Reactivité: Humain, Souris, Rat, Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRS1 est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This phosphorylation site is homologous to Ser302 in Mouse and Rat.

Réactivité croisée: Chévre, Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser307 [TE(p-S)IT]

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-IRS1 (ABIN749873)

Zhang, Qin, Zhang, Li, Zhang, Zhao: "Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes." dans: Molecules (Basel, Switzerland), Vol. 23, Issue 10, (2018) (PubMed).

Luo, Yang, Tang, Yao, Kong, He, Zhou: "Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats." dans: International immunopharmacology, Vol. 28, Issue 1, pp. 744-50, (2015) (PubMed).

Détails sur IRS1

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Autre désignation: IRS-1 (IRS1 Produits)

Synonymes: anticorps HIRS-1, anticorps G972R, anticorps IRS-1, anticorps IRS1IRM, anticorps irs1, anticorps irsu, anticorps IRS1, anticorps irs-1, anticorps irs1-a, anticorps insulin receptor substrate 1, anticorps insulin receptor substrate 2, anticorps insulin receptor substrate 1 S homeolog, anticorps IRS1, anticorps Irs1, anticorps irs2, anticorps irs1.S

Sujet:

Synonyms: HIRS-1, Insulin receptor substrate 1, IRS-1, IRS1

Background: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

ID gène: 3667

UniProt: P35568

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process