Glucagon Receptor anticorps (AA 11-110)

N° du produit ABIN751528

Détail du produit anti-Glucagon Receptor anticorps

Antigène: Glucagon Receptor (GCGR)

Épitope: AA 11-110

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glucagon Receptor est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Glucagon Receptor

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Glucagon Receptor (ABIN751528)

Rafacho, Gonçalves-Neto, Santos-Silva, Alonso-Magdalena, Merino, Taboga, Carneiro, Boschero, Nadal, Quesada: "Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats." dans: PLoS ONE, Vol. 9, Issue 4, pp. e93531, (2014) (PubMed).

Détails sur Glucagon Receptor

Antigène: Glucagon Receptor (GCGR)

Autre désignation: Glucagon Receptor (GCGR Produits)

Synonymes: anticorps GCGR, anticorps GGR, anticorps GR, anticorps glucagon receptor, anticorps GCGR, anticorps Gcgr

Sujet:

Synonyms: GGR, GL-R, Glucagon receptor, GCGR

Background: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

ID gène: 2642

UniProt: P47871

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process