Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

ATG5 anticorps (AA 101-200)

ATG5 Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN752413
  • Antigène Voir toutes ATG5 Anticorps
    ATG5 (ATG5 Autophagy Related 5 (ATG5))
    Épitope
    • 15
    • 11
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-200
    Reactivité
    • 94
    • 47
    • 33
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    Humain, Souris, Rat
    Hôte
    • 69
    • 22
    • 4
    • 1
    Lapin
    Clonalité
    • 70
    • 26
    Polyclonal
    Conjugué
    • 53
    • 7
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ATG5 est non-conjugé
    Application
    • 71
    • 45
    • 30
    • 16
    • 14
    • 14
    • 13
    • 12
    • 7
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Dog,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human APG5L
    Isotype
    IgG
    Top Product
    Discover our top product ATG5 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Li, Li, Wang, Xie, Zhou, Meng, Ding, Ge, Chen: "Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells." dans: Toxicology and applied pharmacology, Vol. 319, pp. 1-11, (2017) (PubMed).

    Lang, Qin, Li, Zhang, Fang, Hao: "Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0129196, (2015) (PubMed).

    Zhang, Ma, Qi, Wei, Zhang, Li, Chiu: "P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis." dans: Oncotarget, Vol. 6, Issue 2, pp. 789-801, (2015) (PubMed).

    Tang, Li, Wei, Zhang, Chiu, Hasenmayer, Zhang, Zhang: "Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma." dans: Cancer letters, Vol. 336, Issue 2, pp. 325-37, (2013) (PubMed).

    Song, Kou, Zou, Gao, Zeng, Xie: "Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens." dans: Neurochemistry international, Vol. 64, pp. 1-8, (2013) (PubMed).

  • Antigène
    ATG5 (ATG5 Autophagy Related 5 (ATG5))
    Autre désignation
    APG5L (ATG5 Produits)
    Sujet

    Synonyms: ASP, APG5, APG5L, hAPG5, APG5-LIKE, Autophagy protein 5, Apoptosis-specific protein, ATG5

    Background: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.

    ID gène
    9474
    UniProt
    Q9H1Y0
    Pathways
    Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy
Vous êtes ici:
Support technique