ATG5 anticorps (AA 101-200)
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- Antigène Voir toutes ATG5 Anticorps
- ATG5 (ATG5 Autophagy Related 5 (ATG5))
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Épitope
- AA 101-200
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ATG5 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Dog,Cow,Pig,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human APG5L
- Isotype
- IgG
- Top Product
- Discover our top product ATG5 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells." dans: Toxicology and applied pharmacology, Vol. 319, pp. 1-11, (2017) (PubMed).
: "Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0129196, (2015) (PubMed).
: "P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis." dans: Oncotarget, Vol. 6, Issue 2, pp. 789-801, (2015) (PubMed).
: "Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma." dans: Cancer letters, Vol. 336, Issue 2, pp. 325-37, (2013) (PubMed).
: "Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens." dans: Neurochemistry international, Vol. 64, pp. 1-8, (2013) (PubMed).
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Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells." dans: Toxicology and applied pharmacology, Vol. 319, pp. 1-11, (2017) (PubMed).
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- Antigène
- ATG5 (ATG5 Autophagy Related 5 (ATG5))
- Autre désignation
- APG5L (ATG5 Produits)
- Sujet
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Synonyms: ASP, APG5, APG5L, hAPG5, APG5-LIKE, Autophagy protein 5, Apoptosis-specific protein, ATG5
Background: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
- ID gène
- 9474
- UniProt
- Q9H1Y0
- Pathways
- Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy
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