Dystroglycan anticorps (pTyr892) (HRP)

N° du produit ABIN753472

Détail du produit anti-Dystroglycan anticorps (HRP)

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Épitope: pTyr892

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dystroglycan est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human DAG1 around the phosphorylation site of Tyr892

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Dystroglycan

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Autre désignation: DAG1 (DAG1 Produits)

Synonymes: anticorps LOC398500, anticorps dag1, anticorps MGC53537, anticorps 156DAG, anticorps A3a, anticorps AGRNR, anticorps DAG, anticorps MDDGC7, anticorps MDDGC9, anticorps DAG1, anticorps RAB7, anticorps dg, anticorps a3a, anticorps dag, anticorps agrnr, anticorps 156dag, anticorps D9Wsu13e, anticorps DG, anticorps Dp427, anticorps Dp71, anticorps CG18250, anticorps CT41273, anticorps DmDG, anticorps Dmel\\CG18250, anticorps atu, anticorps dgn, anticorps dys, anticorps GB14967, anticorps APOJ, anticorps CLI, anticorps RATTRPM2B, anticorps SGP-2, anticorps SGP2, anticorps SP-40, anticorps SP40, anticorps TRPM-2, anticorps TRPM2B, anticorps Trpm2, anticorps Trpmb, anticorps Ala-1, anticorps H9/25, anticorps Ly-27, anticorps Ly-6, anticorps Ly27, anticorps wu:fb83d06, anticorps wu:fi25f06, anticorps wu:fi37b08, anticorps zgc:109786, anticorps DystroGlycaN, anticorps dystroglycan 1 L homeolog, anticorps dystroglycan 1, anticorps dystroglycan 1 S homeolog, anticorps Dystroglycan, anticorps dystroglycan, anticorps clusterin, anticorps lymphocyte antigen 6 complex, anticorps dgn-1, anticorps dag1.L, anticorps dgn-2, anticorps dgn-3, anticorps DAG1, anticorps dag1.S, anticorps Dag1, anticorps dag1, anticorps Dg, anticorps LOC408826, anticorps Clu, anticorps Ly6

Sujet:

Synonyms: DAG1 Tyr892, DAG1 Y892, p-DAG1Tyr892, Alpha Dystroglycan phospho Y892, AGRNR, Alpha-DG, Beta-DG, Beta-dystroglycan, beta Dystroglycan, DAG, Dag1, DAG1_HUMAN, Dystroglycan 1 dystrophin-associated glycoprotein 1, Dystroglycan, Dystrophin-associated glycoprotein 1, 156DAG, A3a, Dystrophin-associated glycoprotein 1.

Background: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]

ID gène: 1605

Pathways: Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus