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LRP5 anticorps (AA 501-600) (Biotin)

LRP5 Reactivité: Souris ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN754080
  • Antigène Voir toutes LRP5 Anticorps
    LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
    Épitope
    • 15
    • 14
    • 12
    • 8
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-600
    Reactivité
    • 62
    • 45
    • 21
    • 1
    • 1
    Souris
    Hôte
    • 66
    • 5
    • 1
    • 1
    Lapin
    Clonalité
    • 69
    • 4
    Polyclonal
    Conjugué
    • 25
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LRP5 est conjugé à/à la Biotin
    Application
    • 37
    • 30
    • 26
    • 13
    • 13
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This antibody will recognize LRP6 due to high sequence similarity.
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Cow,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human LRP5
    Isotype
    IgG
    Top Product
    Discover our top product LRP5 Anticorps primaire
  • Indications d'application
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
    Autre désignation
    LRP5 (LRP5 Produits)
    Synonymes
    anticorps Xlrp5, anticorps bmnd1, anticorps evr1, anticorps evr4, anticorps hbm, anticorps lr3, anticorps lrp5-A, anticorps lrp7, anticorps oppg, anticorps ops, anticorps opta1, anticorps vbch2, anticorps LRP5, anticorps LRP6, anticorps BMND1, anticorps EVR1, anticorps EVR4, anticorps HBM, anticorps LR3, anticorps LRP7, anticorps OPPG, anticorps OPS, anticorps OPTA1, anticorps VBCH2, anticorps mKIAA4142, anticorps low-density lipoprotein receptor-related protein 5, anticorps LDL receptor related protein 5, anticorps LDL receptor related protein 5 L homeolog, anticorps low density lipoprotein receptor-related protein 5, anticorps LDL receptor related protein 5 like, anticorps LOC100147353, anticorps LRP5, anticorps lrp5.L, anticorps lrp5, anticorps Lrp5, anticorps LRP5L
    Sujet

    Synonyms: HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, LRP-5, OPTA1, VBCH2, Low-density lipoprotein receptor-related protein 5, LRP5

    Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

    ID gène
    4041
    UniProt
    O75197
    Pathways
    Signalisation WNT, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation
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