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ZEB1/2 anticorps (AA 211-320)

Reactivité: Humain, Souris, Rat WB, FACS, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN755113
  • Antigène Tous les produits ZEB1/2
    ZEB1/2 (ZEB1, ZEB2)
    Épitope
    AA 211-320
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 15
    Lapin
    Clonalité
    • 15
    Polyclonal
    Conjugué
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ZEB1/2 est non-conjugé
    Application
    Western Blotting (WB), Flow Cytometry (FACS), ELISA
    Specificité
    Antibody will bind to Zinc finger E-box-binding homeobox 1 & 2
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Dog,Cow,Pig,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human ZEB1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • He, Lu, Hu, Zhang, Qin, Wang, Xing, Xi, Wang: "The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation." dans: International journal of molecular sciences, Vol. 16, Issue 7, pp. 16313-29, (2016) (PubMed).

    Xiang, Liu, Chen, Wang, Ma, Wu, Gao: "ZEB1 Expression Is Correlated With Tumor Metastasis and Reduced Prognosis of Breast Carcinoma in Asian Patients." dans: Cancer investigation, Vol. 33, Issue 6, pp. 225-31, (2015) (PubMed).

    Sasaki, Kuniyasu, Luo, Kato, Shinya, Fujii, Ohmori, Yamashita: "Significance of epithelial growth factor in the epithelial-mesenchymal transition of human gallbladder cancer cells." dans: Cancer science, Vol. 103, Issue 6, pp. 1165-71, (2012) (PubMed).

  • Antigène
    ZEB1/2 (ZEB1, ZEB2)
    Autre désignation
    ZEB1/2 (ZEB1/2 Produits)
    Sujet

    Synonyms: AREB 6, AREB6, BZP, Delta crystallin enhancer binding factor 1, DELTA EF1, FECD6, MGC133261, Negative regulator of IL 2, Negative regulator of IL2, NIL 2 A, NIL 2 A zinc finger protein, NIL 2A, NIL-2-A zinc finger protein, NIL2A, Posterior polymorphous corneal dystrophy 3, PPCD3, Represses interleukin 2 expression, TCF 8, TCF-8, TCF8, Transcription factor 8 represses interleukin 2 expression, Transcription factor 8, ZEB 1, ZEB, ZEB1, ZEB1_HUMAN, ZFHEP, ZFHX 1A, ZFHX1A, Zinc finger E box binding homeobox 1, Zinc finger E-box-binding homeobox 1, Zinc finger homeodomain enhancer binding protein, Smad Interacting Protein 1 SIP 1, SIP1 SIP-1, Smad-interacting protein 1, SMADIP 1, SMADIP1, ZEB 2, ZEB2, ZEB2_HUMAN, Zfhx1b, ZFHX1B protein, Zfx1b, Zinc finger E box binding protein 2, Zinc finger E-box-binding homeobox 2, Zinc finger homeobox 1b, zinc finger homeobox protein 1, Zinc finger homeobox protein 1b.

    Background: ZEB1 Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. ZEB2 is a Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

    ID gène
    6935, 9839
    UniProt
    P37275, O60315
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