DDR2 anticorps (AA 245-350)

N° du produit ABIN755218

Détail du produit anti-DDR2 anticorps

Antigène: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Épitope: AA 245-350

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CD167b/DDR2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-DDR2 (ABIN755218)

Zhu, Gillespie, Jackson: "NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4." dans: American journal of physiology. Heart and circulatory physiology, Vol. 309, Issue 9, pp. H1528-42, (2015) (PubMed).

Wang, Wang, Zhao, Li, Deng: "Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts." dans: Biochemical pharmacology, Vol. 85, Issue 10, pp. 1486-94, (2013) (PubMed).

Détails sur DDR2

Antigène: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Autre désignation: CD167b (DDR2 Produits)

Synonymes: anticorps MIG20a, anticorps NTRKR3, anticorps TKT, anticorps TYRO10, anticorps AW495251, anticorps Ntrkr3, anticorps tyro10, anticorps DDR2, anticorps Tyro10, anticorps ddr2, anticorps si:ch211-193c2.1, anticorps discoidin domain receptor tyrosine kinase 2, anticorps discoidin domain receptor family, member 2, anticorps discoidin domain receptor family, member 2, like, anticorps DDR2, anticorps Ddr2, anticorps ddr2l

Sujet:

Synonyms: TKT, MIG2a, NTRKR3, TYRO1, Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO1, CD167b, DDR2

Background: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

ID gène: 4921

UniProt: Q16832

Pathways: Signalisation RTK