ADAM11 anticorps (AA 351-450) (Biotin)

N° du produit ABIN758743

Détail du produit anti-ADAM11 anticorps (Biotin)

Antigène: ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))

Épitope: AA 351-450

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADAM11 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris

Homologie: Rat,Cow,Sheep

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ADAM11

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ADAM11

Antigène: ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))

Autre désignation: ADAM11 (ADAM11 Produits)

Synonymes: anticorps DKFZp459F101, anticorps AW060611, anticorps Mdc, anticorps MDC, anticorps mdc, anticorps mdc11a, anticorps xMDC11, anticorps ADAM metallopeptidase domain 11, anticorps a disintegrin and metallopeptidase domain 11, anticorps ADAM metallopeptidase domain 11 L homeolog, anticorps ADAM11, anticorps adam11, anticorps Adam11, anticorps adam11.L

Sujet:

Synonyms: A disintegrin and metalloproteinase domain 11, ADA11_HUMAN, MDC, Metalloproteinase like, disintegrin like, and cysteine rich protein.

Background: ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.

ID gène: 4185