ADAM11 anticorps (AA 351-450) (Cy5)
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- Antigène Voir toutes ADAM11 Anticorps
- ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))
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Épitope
- AA 351-450
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ADAM11 est conjugé à/à la Cy5
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris
- Homologie
- Rat,Cow,Sheep
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human ADAM11
- Isotype
- IgG
- Top Product
- Discover our top product ADAM11 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))
- Autre désignation
- ADAM11 (ADAM11 Produits)
- Synonymes
- anticorps DKFZp459F101, anticorps AW060611, anticorps Mdc, anticorps MDC, anticorps mdc, anticorps mdc11a, anticorps xMDC11, anticorps ADAM metallopeptidase domain 11, anticorps a disintegrin and metallopeptidase domain 11, anticorps ADAM metallopeptidase domain 11 L homeolog, anticorps ADAM11, anticorps adam11, anticorps Adam11, anticorps adam11.L
- Sujet
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Synonyms: A disintegrin and metalloproteinase domain 11, ADA11_HUMAN, MDC, Metalloproteinase like, disintegrin like, and cysteine rich protein.
Background: ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.
- ID gène
- 4185
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