WASF1 anticorps (AA 481-559)

N° du produit ABIN759461

Détail du produit anti-WASF1 anticorps

Antigène: WASF1 (WAS Protein Family, Member 1 (WASF1))

Épitope: AA 481-559

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WASF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human WAVE 1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur WASF1

Antigène: WASF1 (WAS Protein Family, Member 1 (WASF1))

Autre désignation: WAVE 1 (WASF1 Produits)

Synonymes: anticorps scar1, anticorps wave1, anticorps ATRANGAP2, anticorps ATSCAR1, anticorps SCAR1, anticorps T14G11.27, anticorps T14G11_27, anticorps WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY VERPROLIN HOMOLOGOUS PROTEIN 1, anticorps wave, anticorps WAVE, anticorps WAVE1, anticorps AI195380, anticorps AI838537, anticorps Scar, anticorps WAVE-1, anticorps WAS protein family member 1 S homeolog, anticorps SCAR family protein, anticorps WAS protein family member 1, anticorps WAS protein family, member 1, anticorps wasf1.S, anticorps AT2G34150, anticorps wasf1, anticorps WASF1, anticorps Wasf1

Sujet:

Synonyms: Protein WAVE-1, Protein WAVE1, SCAR1, Similar to a plant extensin like protein, Verprolin homology domain containing protein 1, Verprolin homology domain-containing protein 1, WAS protein family, member 1, Wasf1, WASF1_HUMAN, WASL, WASP family 1, WASP family protein member 1, WAVE, WAVE1, Wiskott Aldrich syndrome protein family member 1, Wiskott-Aldrich syndrome protein family member 1.

Background: WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the Actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating Actin reorganization downstream of the Rho family of small GTPases. The protein homologs WAVE1 and WAVE2 regulate membrane ruffling by inducing the formation of Actin filament clusters in response to GTP binding and by activating Rac. They mediate Actin polymerization by cooperating with the Arp2/3 complex, thereby promoting the formation of Actin filaments. WAVE1, which is also designated SCAR (suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed, with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases with Actin and plays a role in the transduction of signals involving changes in cell shape, function or motility.

ID gène: 8936

Pathways: Signalisation RTK, Regulation of Actin Filament Polymerization