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POLA1 anticorps (AA 1231-1350)

POLA1 Reactivité: Humain WB, ELISA, IHC (fro), IF (cc), IF (p), IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN763391
  • Antigène Voir toutes POLA1 Anticorps
    POLA1 (DNA Polymerase alpha (POLA1))
    Épitope
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1231-1350
    Reactivité
    • 31
    • 12
    • 11
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 39
    • 5
    Lapin
    Clonalité
    • 40
    • 4
    Polyclonal
    Conjugué
    • 20
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Cet anticorp POLA1 est non-conjugé
    Application
    • 19
    • 11
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Human,Mouse,Rat,Dog,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DPOLA/DNA polymerase alpha
    Isotype
    IgG
    Top Product
    Discover our top product POLA1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    POLA1 (DNA Polymerase alpha (POLA1))
    Autre désignation
    Dna Polymerase alpha (POLA1 Produits)
    Synonymes
    anticorps pola, anticorps AW321876, anticorps Pola, anticorps POLA, anticorps p180, anticorps polymerase (DNA directed), alpha 1, catalytic subunit S homeolog, anticorps polymerase (DNA directed), alpha 1, anticorps DNA polymerase alpha 1, catalytic subunit, anticorps pola1.S, anticorps Pola1, anticorps POLA1
    Sujet

    Synonyms: DNA polymerase alpha 1 catalytic subunit, DNA polymerase alpha catalytic subunit, DNA polymerase alpha catalytic subunit p180, DNA polymerase alpha p180 subunit, DPOLA_HUMAN, P180, p180 subunit, POLA, POLA1, Polymerase DNA directed, alpha 1, catalytic subunit, Polymerase DNA-directed, alpha 70kD.

    Background: Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes.

    ID gène
    5422
    Pathways
    SARS-CoV-2 Protein Interactome
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