Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

ASAH1 anticorps (AA 25-125)

ASAH1 Reactivité: Humain WB, IHC (p), EIA Hôte: Souris Monoclonal 1A7 unconjugated
N° du produit ABIN782337
  • Antigène Voir toutes ASAH1 Anticorps
    ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
    Épitope
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 25-125
    Reactivité
    • 29
    • 22
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 40
    • 4
    Souris
    Clonalité
    • 40
    • 4
    Monoclonal
    Conjugué
    • 20
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ASAH1 est non-conjugé
    Application
    • 33
    • 14
    • 13
    • 13
    • 10
    • 9
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    Recognizes Acid ceramidase ASAH1.
    Réactivité croisée (Details)
    Species reactivity (tested):Human.
    Purification
    Protein A Chromatography
    Immunogène
    ASAH1 antibody was raised against ASAH1 (NP_808592, 25 a.a. ~ 125 a.a) partial recombinant protein with GST tag.
    Clone
    1A7
    Isotype
    IgG3
    Top Product
    Discover our top product ASAH1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS, pH 7.2
    Conseil sur la manipulation
    Avoid freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at -20° or -80 °C.
  • Antigène
    ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
    Autre désignation
    Acid Ceramidase (ASAH1 Produits)
    Synonymes
    anticorps AC, anticorps ACDase, anticorps ASAH, anticorps PHP, anticorps PHP32, anticorps SMAPME, anticorps 2310081N20Rik, anticorps Asah, anticorps MGC82286, anticorps asah1, anticorps zgc:101637, anticorps ASAH1, anticorps zgc:66026, anticorps N-acylsphingosine amidohydrolase 1, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1 L homeolog, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1a, anticorps Acid ceramidase, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1b, anticorps ASAH1, anticorps Asah1, anticorps asah1.L, anticorps asah1a, anticorps asah-1, anticorps asah1b
    Sujet
    Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.Synonyms: ASAH, ASAH1, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase, PHP32, Putative 32 kDa heart protein
    ID gène
    427
    NCBI Accession
    NP_001120977
    UniProt
    Q13510
Support technique