ASAH1 anticorps (AA 25-125)

N° du produit ABIN782337

Détail du produit anti-ASAH1 anticorps

Antigène: ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))

Épitope: AA 25-125

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ASAH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: Recognizes Acid ceramidase ASAH1.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Protein A Chromatography

Immunogène: ASAH1 antibody was raised against ASAH1 (NP_808592, 25 a.a. ~ 125 a.a) partial recombinant protein with GST tag.

Clone: 1A7

Isotype: IgG3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20° or -80 °C.

Détails sur ASAH1

Antigène: ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))

Autre désignation: Acid Ceramidase (ASAH1 Produits)

Synonymes: anticorps AC, anticorps ACDase, anticorps ASAH, anticorps PHP, anticorps PHP32, anticorps SMAPME, anticorps 2310081N20Rik, anticorps Asah, anticorps MGC82286, anticorps asah1, anticorps zgc:101637, anticorps ASAH1, anticorps zgc:66026, anticorps N-acylsphingosine amidohydrolase 1, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1 L homeolog, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1a, anticorps Acid ceramidase, anticorps N-acylsphingosine amidohydrolase (acid ceramidase) 1b, anticorps ASAH1, anticorps Asah1, anticorps asah1.L, anticorps asah1a, anticorps asah-1, anticorps asah1b

Sujet: Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.Synonyms: ASAH, ASAH1, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase, PHP32, Putative 32 kDa heart protein

ID gène: 427

NCBI Accession: NP_001120977

UniProt: Q13510