ITK anticorps (AA 596-607)
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- Antigène Voir toutes ITK Anticorps
- ITK (IL2-Inducible T-Cell Kinase (ITK))
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Épitope
- AA 596-607
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Reactivité
- Humain
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ITK est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody reacts to Interleukin 2 Tyrosine Kinase (ITK).
- Purification
- Immunoaffinity Chromatography
- Immunogène
- Synthetic peptide C-KERPEDRPAFSR from positions 596-607 of human ITK (NP_005537.3). Genename: ITK
- Isotype
- IgG
- Top Product
- Discover our top product ITK Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0,5 mg/mL
- Buffer
- Tris saline buffer, pH 7.3 containing 0.5 % BSA as stabilizer and 0.02 % sodium azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
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- Antigène
- ITK (IL2-Inducible T-Cell Kinase (ITK))
- Autre désignation
- Tyrosine-Protein Kinase ITK/TSK (ITK Produits)
- Synonymes
- anticorps Emt, anticorps Tcsk, anticorps Tsk, anticorps EMT, anticorps LPFS1, anticorps LYK, anticorps PSCTK2, anticorps IL2 inducible T cell kinase, anticorps IL2 inducible T-cell kinase, anticorps IL2-inducible T-cell kinase, anticorps Itk, anticorps ITK
- Sujet
- Interleukin-2 tyrosine kinase (ITK), a BTK/TEC type tyrosine kinase, is critical for efficient signaling downstream of the T cell receptor. Itk is directly phosphorylated and activated by Lck. Subsequently, Itk activates phospholipase C-gamma1, leading to calcium mobilization and extracellular signal-regulated kinase/mitogen-activated protein kinase activation. Itk contains five domains in addition to the catalytic domain: pleckstrin homology, Tec homology which contains a proline-rich region, Src homology 3, and Src homology 2.Synonyms: EMT, Kinase EMT, LYK, T-cell-specific kinase, Tyrosine-protein kinase Lyk
- ID gène
- 3702
- NCBI Accession
- NP_005537
- UniProt
- Q08881
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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