GSAP anticorps (C-Term)

N° du produit ABIN783371

Détail du produit anti-GSAP anticorps

Antigène: GSAP (PION) (Pigeon Homolog (PION))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSAP est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects PION at C-term. Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide near the carboxy terminus of human PION

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur GSAP

Antigène: GSAP (PION) (Pigeon Homolog (PION))

Autre désignation: PION / GSAP (PION Produits)

Synonymes: anticorps PION, anticorps A530088I07Rik, anticorps Pion, anticorps gamma-secretase activating protein, anticorps GSAP, anticorps Gsap

Sujet: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer s disease. The β-amyloid protein precursor (APP) is cleaved by one of two β-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for γ?secretase to generate the 4 kDa amyloid-β peptide (Aβ), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog

ID gène: 54103

NCBI Accession: NP_059135

UniProt: A4D1B5