SP110 anticorps (C-Term)

N° du produit ABIN783558

Détail du produit anti-SP110 anticorps

Antigène: SP110 (SP110 Nuclear Body Protein (SP110))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SP110 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects SP110 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide near the carboxy terminus of the human IPR1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur SP110

Antigène: SP110 (SP110 Nuclear Body Protein (SP110))

Autre désignation: SP110 (SP110 Produits)

Synonymes: anticorps SP110, anticorps IFI41, anticorps IFI75, anticorps IPR1, anticorps VODI, anticorps 5031415C07Rik, anticorps 52kDa, anticorps 5830484A20Rik, anticorps ENSMUSG00000075603, anticorps Ifi75, anticorps Ipr1, anticorps SP110 nuclear body protein, anticorps Sp110 nuclear body protein, anticorps SP110, anticorps Sp110

Sujet: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.Synonyms: FLJ22835, IPR1, SP-110, SP110 nuclear body protein, Speckled 110 kD, VODI

ID gène: 3431

NCBI Accession: NP_001171944

UniProt: Q9HB58