ATG101 anticorps (Center)

N° du produit ABIN783665

Détail du produit anti-ATG101 anticorps

Antigène: ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG101 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes ATG101 and is predicted to not cross-react with other TG members.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity Chromatography purified via peptide column

Immunogène: 16 amino acid peptide near the center of Human ATG101

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Antibody is supplied in PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ATG101

Antigène: ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))

Autre désignation: ATG101 (C12orf44 Produits)

Synonymes: anticorps ATG101, anticorps C12orf44, anticorps AA407441, anticorps AU022967, anticorps Atg101, anticorps atg101, anticorps im:6904812, anticorps autophagy related 101, anticorps ATG101, anticorps Atg101, anticorps atg101

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG101 is a recently discovered protein that stabilizes ATG13, another autophagy protein that forms a complex with the mammalian homologs of ATG1, ULK1 and ULK2, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions, inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. ATG101 also interacts with ULK1 and is essential for autophagy.Synonyms: Autophagy-related protein 101, C12orf44, PP894, UPF0453 protein C12orf44

ID gène: 60673

NCBI Accession: NP_001092143

UniProt: Q9BSB4

Pathways: Autophagy