NLRC3 anticorps (Center)

N° du produit ABIN783697

Détail du produit anti-NLRC3 anticorps

Antigène: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRC3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects NOD3 at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the center of human NOD3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur NLRC3

Antigène: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Autre désignation: NOD3 (NLRC3 Produits)

Synonymes: anticorps NLRC3, anticorps nod3, anticorps NLR-A3, anticorps NOD3, anticorps CLR16.2, anticorps D230007K08Rik, anticorps mFLJ00348, anticorps Nlrc3-ps1, anticorps RGD1304902, anticorps NLR family CARD domain containing 3, anticorps NLR family, CARD domain containing 3, anticorps NLRC3, anticorps nlrc3, anticorps Nlrc3

Sujet: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-?B, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.Synonyms: CLR16.2, FLJ00348, NLRC3, NOD3

ID gène: 197358

NCBI Accession: NP_849172

UniProt: Q7RTR2