ZBP1 anticorps (C-Term)

N° du produit ABIN783819

Détail du produit anti-ZBP1 anticorps

Antigène: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to ZBP1.

Purification: Affinity chromatography

Immunogène: 18 amino acid peptide from near the carboxy terminus of human ZBP1.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur ZBP1

Antigène: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Autre désignation: ZBP1 (ZBP1 Produits)

Synonymes: anticorps C20orf183, anticorps DAI, anticorps DLM-1, anticorps DLM1, anticorps 2010010H03Rik, anticorps Dai, anticorps Dlm1, anticorps mZaDLM, anticorps ZBP1, anticorps Z-DNA binding protein 1, anticorps ZBP1, anticorps Zbp1

Sujet: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Za domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.Synonyms: C20orf183, DLM1, Z-DNA-binding protein 1

ID gène: 81030

NCBI Accession: NP_001153889

UniProt: Q9H171