MAPT anticorps

N° du produit ABIN783852

Détail du produit anti-MAPT anticorps

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody recognizes mainly the truncated Tau (~30 kDa) in samples from human, mouse and rat origins. Other isoforms of Tau at 35 kDa, 60 kDa and 80 kDa can also be recognized.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat, chicken, bovine

Purification: Affinity chromatography

Immunogène: Synthetic peptide surrounding amino acid 395 of rat Tau

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store at -20 °C. For long term storage, aliquot and store at -70 °C.

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: MAPT / tau (MAPT Produits)

Synonymes: anticorps DDPAC, anticorps FTDP-17, anticorps MAPTL, anticorps MSTD, anticorps MTBT1, anticorps MTBT2, anticorps PPND, anticorps TAU, anticorps AI413597, anticorps AW045860, anticorps Mtapt, anticorps Tau, anticorps RNPTAU, anticorps pTau, anticorps tau, anticorps xtp, anticorps MAPT, anticorps PHF-tau, anticorps slc6a6, anticorps taut, anticorps wu:fc26e12, anticorps microtubule associated protein tau, anticorps microtubule-associated protein tau, anticorps microtubule associated protein tau S homeolog, anticorps Microtubule-associated protein tau, anticorps solute carrier family 6 (neurotransmitter transporter), member 6b, anticorps MAPT, anticorps Mapt, anticorps mapt.S, anticorps LOC5580230, anticorps CpipJ_CPIJ013260, anticorps tau, anticorps slc6a6b

Sujet: Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer's disease.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

ID gène: 4137

NCBI Accession: NP_001116538

UniProt: P10636

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size