anticorps ITI-HC4, anticorps Itih-4, anticorps GP120, anticorps H4P, anticorps IHRP, anticorps ITIHL1, anticorps PK-120, anticorps PK120, anticorps inter alpha-trypsin inhibitor, heavy chain 4, anticorps inter-alpha-trypsin inhibitor heavy chain family member 4, anticorps inter-alpha-trypsin inhibitor heavy chain family, member 4, anticorps Itih4, anticorps ITIH4
Sujet
The inter-a-trypsin inhibitor (ITI, IaI) family, a typical and classical example for protein-glycosaminoglycanprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family, it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.Synonyms: Gp120, IHRP, ITI heavy chain H4, ITI-HC4, ITIHL1, Inter-alpha-inhibitor heavy chain 4, Inter-alpha-trypsin inhibitor family heavy chain-related protein, Inter-alpha-trypsin inhibitor heavy chain H4, PK120, Plasma kallikrein sensitive glycoprotein 120