anticorps RPIP1, anticorps MGC80558, anticorps RGS14, anticorps rgs14, anticorps wu:fi04g12, anticorps regulator of G protein signaling 14, anticorps regulator of G-protein signaling 14, anticorps regulator of G-protein signaling 14 L homeolog, anticorps regulator of G-protein signalling 14, anticorps regulator of G protein signaling 14a, anticorps RGS14, anticorps Rgs14, anticorps rgs14.L, anticorps rgs14, anticorps rgs14a
Sujet
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.Synonyms: Regulator of G-protein signaling 14