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HGS anticorps (Internal Region)

HGS Reactivité: Humain, Souris, Rat WB, IF, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN784218
  • Antigène Voir toutes HGS Anticorps
    HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
    Épitope
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 44
    • 30
    • 21
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 38
    • 5
    • 1
    Lapin
    Clonalité
    • 41
    • 3
    Polyclonal
    Conjugué
    • 32
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HGS est non-conjugé
    Application
    • 36
    • 21
    • 20
    • 15
    • 9
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects endogenous levels of total HGS protein.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity Chromatography.
    Immunogène
    Synthetic peptide - KLH conjugated Remarks: Antigen Modification: Internal
    Isotype
    IgG
    Top Product
    Discover our top product HGS Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
    Autre désignation
    HGS / HRS (HGS Produits)
    Synonymes
    anticorps HRS, anticorps Hrs, anticorps fi34f05, anticorps zgc:63492, anticorps wu:fi34f05, anticorps Hgr, anticorps ZFYVE8, anticorps CG2903, anticorps Dmel\\CG2903, anticorps HRS-2, anticorps Vps27, anticorps hrs, anticorps l(2)23AB5, anticorps l(2)23Ad, anticorps l(2)23Ad(Hrs), anticorps vps27, anticorps hgs, anticorps hepatocyte growth factor-regulated tyrosine kinase substrate, anticorps HGF-regulated tyrosine kinase substrate, anticorps Hepatocyte growth factor regulated tyrosine kinase substrate, anticorps hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog, anticorps HGS, anticorps Hgs, anticorps hgs, anticorps Hrs, anticorps hgs.L
    Sujet
    HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.Synonyms: Hepatocyte growth factor-regulated tyrosine kinase substrate, Protein pp110
    ID gène
    9146
    NCBI Accession
    NP_004703
    Pathways
    EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
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