Specific for the ~35 kDa Clavesin 1/2 protein doublet in Western blots of Rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are Clavesin 1 and 2, respectively.
Réactivité croisée (Details)
Species reactivity (expected):Human and Mouse. Species reactivity (tested):Rat.
Purification
Affinity Chromatography.
Immunogène
Synthetic peptide KLH-conjugated corresponding to amino acid residues from the C-terminal region of Rat Clavesin-1. Genename: CLVS1/2
Isotype
IgG
Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS containing 50 % Glycerol.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
Store the antibody undiluted (in aliquots) at -20 °C.
Antigène
Clvs1/2
(Clavesin 1/2 (Clvs1/2))
Sujet
Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).Synonyms: C6orf212, C6orf213, CLVS1, CLVS2, CRALBPL, Cellular retinaldehyde-binding protein-like, RLBP1L1, RLBP1L2, Retinaldehyde-binding protein 1-like 1/2