LY75/DEC-205 anticorps (PE)

N° du produit ABIN807925

Détail du produit anti-LY75/DEC-205 anticorps (PE)

Antigène: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LY75/DEC-205 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody HD30 recognizes an extracellular epitope of CD205, an approx. 200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Recombinant Fc-tagged human CD205

Clone: HD30

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Commentaires:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Stockage

Reconstitution: No reconstitution is necessary.

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.
Avoid prolonged exposure to light.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-LY75/DEC-205 (PE) (ABIN807925)

Park, Rodriguez, Ueta, Lee, Pack, Matsuno, Steinman: "Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals." dans: Journal of immunological methods, Vol. 377, Issue 1-2, pp. 15-22, (2012) (PubMed).

Détails sur LY75/DEC-205

Antigène: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Autre désignation: CD205 (LY75 Produits)

Synonymes: anticorps LY75, anticorps MGC140308, anticorps DEC205, anticorps im:7150926, anticorps si:dkey-78p20.2, anticorps LYT75, anticorps CD205, anticorps DEC-205, anticorps CLEC13B, anticorps GP200-MR6, anticorps LY-75, anticorps RGD1565962, anticorps Ly-75, anticorps lymphocyte antigen 75, anticorps CD205 protein, anticorps CD302 antigen, anticorps LY75, anticorps Cyan7822_2917, anticorps LY5, anticorps ly75, anticorps cd205, anticorps LOC100380704, anticorps LOC100433861, anticorps LOC100483541, anticorps Ly75

Sujet: Lymphocyte antigen 75,CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.,DEC-205, LY75, CLEC13B

ID gène: 4065

UniProt: O60449