Integrin beta 3 anticorps

N° du produit ABIN810075

Détail du produit anti-Integrin beta 3 anticorps

Antigène: Integrin beta 3 (ITGB3)

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin beta 3 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: The mouse monoclonal antibody VIPL2 recognizes an extracellular epitope of CD61, a 90-110 kDa transmembrane glycoprotein of integrin family, expressed on platelets, megacaryocytes, osteoclasts, endothelial cells and other cell types, including leucocytes and smooth muscle cells.

Réactivité croisée (Details): Human, Non-Human Primates

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Clone: VIPL2

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-Integrin beta 3 (ABIN810075)

Barrett, Dai, Gamberg, Gallant, Grant: "Circulating CD14-CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10." dans: Journal of leukocyte biology, Vol. 82, Issue 1, pp. 152-60, (2007) (PubMed).

Mondal, Williams, Ali, Eilers, Agrawal: "The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells." dans: Experimental biology and medicine (Maywood, N.J.), Vol. 230, Issue 9, pp. 631-44, (2005) (PubMed).

Williams, Mondal, Agrawal: "The HIV-1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP." dans: Experimental biology and medicine (Maywood, N.J.), Vol. 230, Issue 11, pp. 872-84, (2005) (PubMed).

Roberts, Woods, Dale, Van Der Sluijs, Norman: "Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins." dans: Molecular and cellular biology, Vol. 24, Issue 4, pp. 1505-15, (2004) (PubMed).

Ciarlet, Crawford, Cheng, Blutt, Rice, Bergelson, Estes: "VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment." dans: Journal of virology, Vol. 76, Issue 3, pp. 1109-23, (2002) (PubMed).

Dzionek, Fuchs, Schmidt, Cremer, Zysk, Miltenyi, Buck, Schmitz: "BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6037-46, (2000) (PubMed).

Détails sur Integrin beta 3

Antigène: Integrin beta 3 (ITGB3)

Autre désignation: CD61 (ITGB3 Produits)

Synonymes: anticorps BDPLT16, anticorps BDPLT2, anticorps CD61, anticorps GP3A, anticorps GPIIIa, anticorps GT, anticorps INGRB3, anticorps integrin, anticorps INTB3, anticorps GPIIIA, anticorps cd61, anticorps gp3a, anticorps itgb3, anticorps itgb3.2, anticorps itgb3.1, anticorps integrin subunit beta 3, anticorps integrin beta 3, anticorps integrin subunit beta 3 L homeolog, anticorps integrin beta 3a, anticorps integrin beta 3b, anticorps ITGB3, anticorps Itgb3, anticorps itgb3.L, anticorps itgb3a, anticorps itgb3b

Sujet: Integrin subunit beta 3,CD61 (beta3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 Molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.,integrin beta 3, ITGB3, GP3A

ID gène: 3690

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex