Aquaporin 4 anticorps (C-Term)

N° du produit ABIN863209

Détail du produit anti-Aquaporin 4 anticorps

Antigène: Aquaporin 4 (AQP4)

Épitope: C-Term

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aquaporin 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Detects ~35 kDa. May detect larger glycosylated bands ~50 kDa.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein A Purified

Immunogène: Produced against the C-terminal peptide (Sequence N-CTKGSYMEVEDNRSQVETED) of rat aquaporin 4

Information d'application

Indications d'application:

• WB (1:2000)
• IHC (1:200)
• ICC/IF (1:400)
• optimal dilutions for assays should be determined by the user.

Commentaires:

0.5 μg/ml of ABIN863209 was sufficient for detection of aquaporin 4 in 10 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Références pour anticorps anti-Aquaporin 4 (ABIN863209)

Gatto, Amin, Deyoung, Hey, Mareci, Magin: "Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice." dans: Translational neurodegeneration, Vol. 7, pp. 20, (2018) (PubMed).

Détails sur Aquaporin 4

Antigène: Aquaporin 4 (AQP4)

Autre désignation: Aquaporin 4 (AQP4 Produits)

Synonymes: anticorps zgc:100922, anticorps si:ch211-192k9.1, anticorps AQP4, anticorps LOC100232616, anticorps HMIWC2, anticorps MIWC, anticorps WCH4, anticorps AQP-4, anticorps AQP4.M23, anticorps MIWC2, anticorps Miwc, anticorps aquaporin-4, anticorps aquaporin 4, anticorps aquaporin 4 L homeolog, anticorps aqp4, anticorps AQP4, anticorps aqp4.L, anticorps Aqp4

Sujet: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 4 is constitutively expressed in the basolateral cell membrane of principal collecting duct cells in the kidney and provide a pathway for water to exit these cells (3). It is also expressed in astrocytes and is up regulated by direct insult to the CNS (4). Aquaporin 4 has been proposed as the primary autoimmune target in neuromyelitis optica ( 5, 6).

ID gène: 25293

NCBI Accession: NP_036957

UniProt: P47863

Pathways: Sensory Perception of Sound