tau anticorps (pSer416)
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- Antigène Voir toutes tau Anticorps
- tau (tau Protein)
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Épitope
- pSer416
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Reactivité
- Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp tau est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- The antibody detects endogenous levels of Tau only when phosphorylated at serine 416.
- Purification
- Affinity purified
- Immunogène
- Peptide sequence around phosphorylation site of pSer416 (T-G-S (p) -I-D) derived from Rat Tau. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Top Product
- Discover our top product tau Anticorps primaire
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- Indications d'application
- Western blotting: 1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Antigène
- tau (tau Protein)
- Autre désignation
- Tau (tau Produits)
- Synonymes
- anticorps DDPAC, anticorps FTDP-17, anticorps MAPTL, anticorps MSTD, anticorps MTBT1, anticorps MTBT2, anticorps PPND, anticorps TAU, anticorps tau, anticorps PHF-tau, anticorps microtubule associated protein tau, anticorps MAPT
- Sujet
- Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies
- Poids moléculaire
- 78 kDa
- ID gène
- 29477
- NCBI Accession
- NP_058908
- UniProt
- P19332
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