KAP1 anticorps (AA 827-831)
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- Antigène Voir toutes KAP1 (TRIM28) Anticorps
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
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Épitope
- AA 827-831
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KAP1 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- The antibody detects endogenous level of total TIF1b protein.
- Purification
- Affinity purified
- Immunogène
- Peptide sequence around AA 827-831 (L-S-G-G-P) derived from Human TIF1b. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Top Product
- Discover our top product TRIM28 Anticorps primaire
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- Indications d'application
- Western blotting: 1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Antigène
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
- Autre désignation
- TIF1beta (TRIM28 Produits)
- Synonymes
- anticorps KAP1, anticorps RNF96, anticorps TF1B, anticorps TIF1B, anticorps TRIM28, anticorps kap1, anticorps rnf96, anticorps tf1b, anticorps tif1b, anticorps AA408787, anticorps KAP-1, anticorps KRIP-1, anticorps Tif1b, anticorps Tif1beta, anticorps Kap1, anticorps Krip1, anticorps TIF1BETA, anticorps tripartite motif containing 28, anticorps tripartite motif containing 28 L homeolog, anticorps tripartite motif-containing 28, anticorps TRIM28, anticorps trim28.L, anticorps Trim28
- Sujet
- Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.
- Poids moléculaire
- 110 kDa
- ID gène
- 10155
- NCBI Accession
- NP_005753
- UniProt
- Q13263
- Pathways
- Signalisation Hedgehog, Positive Regulation of Response to DNA Damage Stimulus
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