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Separase anticorps (AA 1851-1950)

ESPL1 Reactivité: Humain ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN872482
  • Antigène Voir toutes Separase (ESPL1) Anticorps
    Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))
    Épitope
    • 17
    • 15
    • 14
    • 9
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1851-1950
    Reactivité
    • 93
    • 10
    • 1
    Humain
    Hôte
    • 88
    • 5
    • 1
    Lapin
    Clonalité
    • 89
    • 5
    Polyclonal
    Conjugué
    • 30
    • 9
    • 9
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Separase est non-conjugé
    Application
    • 47
    • 39
    • 25
    • 25
    • 21
    • 13
    • 11
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Separase
    Isotype
    IgG
    Top Product
    Discover our top product ESPL1 Anticorps primaire
  • Indications d'application
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))
    Autre désignation
    Separase (ESPL1 Produits)
    Synonymes
    anticorps ESP1, anticorps SEPA, anticorps mp:zf637-3-001691, anticorps AL024103, anticorps AU045071, anticorps Cerp, anticorps PRCE, anticorps SSE, anticorps extra spindle pole bodies like 1, separase, anticorps extra spindle poles like 1, anticorps extra spindle pole bodies 1, separase, anticorps ESPL1, anticorps espl1, anticorps Espl1
    Sujet

    Synonyms: Caspase like protein ESPL1, ESP 1, ESP1, ESP-1, ESPL 1, ESPL1, ESPL-1, Extra spindle poles like 1, Extra spindle poles like 1 protein, Separin, Similar to fission yeast cut1and gene, SSE, Separase, ESPL1_HUMAN.

    Background: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21, MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].

    ID gène
    9700
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