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DEDD2 anticorps (AA 201-300)

DEDD2 Reactivité: Rat ELISA, IF (cc), IF (p), IHC (fro), IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN872592
  • Antigène Voir toutes DEDD2 Anticorps
    DEDD2 (Death Effector Domain Containing 2 (DEDD2))
    Épitope
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    Reactivité
    • 18
    • 17
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 31
    Lapin
    Clonalité
    • 31
    Polyclonal
    Conjugué
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DEDD2 est non-conjugé
    Application
    • 12
    • 12
    • 8
    • 5
    • 2
    • 2
    • 2
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Rat
    Homologie
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DEDD2
    Isotype
    IgG
    Top Product
    Discover our top product DEDD2 Anticorps primaire
  • Indications d'application
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    DEDD2 (Death Effector Domain Containing 2 (DEDD2))
    Autre désignation
    DEDD2 (DEDD2 Produits)
    Synonymes
    anticorps FLAME-3, anticorps MGC145883, anticorps 2410050E11Rik, anticorps DEDD2, anticorps death effector domain containing 2, anticorps death effector domain containing 2 L homeolog, anticorps death effector domain-containing DNA binding protein 2, anticorps DEDD2, anticorps dedd2.L, anticorps dedd2, anticorps Dedd2
    Sujet

    Synonyms: Death effector domain containing 2, DED containing protein FLAME 3, DNA binding death effector domain containing protein 2, FADD like anti apoptotic molecule 3, FLAME 3,

    Background: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

    ID gène
    162989
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