SIRT4 anticorps (AA 51-150)
(2 références)-
- Antigène Voir toutes SIRT4 Anticorps
- SIRT4 (Sirtuin 4 (SIRT4))
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Épitope
- AA 51-150
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Reactivité
- Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SIRT4 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Souris, Rat
- Homologie
- Human,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish,Drosophila
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4
- Isotype
- IgG
- Top Product
- Discover our top product SIRT4 Anticorps primaire
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anti-Sirtuin 4 (SIRT4) (AA 28-314) antibody
SIRT4 Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 60-255) antibodySIRT4 Reactivité: Rat WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 215-314) antibodySIRT4 Reactivité: Humain ELISA, ICC, FACS Hôte: Souris Monoclonal 6G6D2 unconjugated
anti-Sirtuin 4 (SIRT4) (C-Term) antibodyVerified SIRT4 Reactivité: Humain WB, IHC, ELISA Hôte: Chèvre Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (Middle Region) antibodySIRT4 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc, Cheval, Lapin, Mouton, Cobaye WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 29-260) antibodySIRT4 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 26-333) antibodySIRT4 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 215-314) antibodySIRT4 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 1C8 unconjugated
anti-Sirtuin 4 (SIRT4) (AA 216-265) antibodySIRT4 Reactivité: Humain, Chien, Porc, Singe WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (N-Term) antibodySIRT4 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc, Cheval, Lapin, Mouton, Cobaye, Chévre, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- SIRT4 (Sirtuin 4 (SIRT4))
- Autre désignation
- SIRT4 (SIRT4 Produits)
- Synonymes
- anticorps SIRT4, anticorps im:7139453, anticorps SIR2L4, anticorps 4930596O17Rik, anticorps sirtuin 4, anticorps SIRT4, anticorps sirt4, anticorps Sirt4
- Sujet
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Synonyms: SIR2L4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4, Regulatory protein SIR2 homolog 4, SIR2-like protein 4, SIRT4
Background: Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
- ID gène
- 23409
- UniProt
- Q9Y6E7
- Pathways
- Negative Regulation of Hormone Secretion
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